Bifidobacteria isolated from vaginal and gut microbiomes are indistinguishable by comparative genomics.

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PubMed ID: 29684056

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Freitas AC, Hill JE

PLoS One. 2018. doi: 10.1371/journal.pone.0196290

COMMENT: In this work the genomes of Bifidobacterium breve and Bifidobacterium longum of gut and vaginal isolates were comapared to assess whether they were distinguishable based on their genome content.

In summary, these were the results of that comparison:

Comparison of the general genome features showed that vaginal and gut isolates did not differ in size, GC content, number of genes and CRISPR, either for B. breve or B. longum. Average nucleotide identity and whole genome phylogeny analysis revealed that vaginal and gut isolates did not cluster separately. Vaginal and gut isolates also had a similar COG (Cluster of Orthologous Group) category distribution.

Hence, it appears that, probably, vaginal and gut microbiomes are colonized by the same communities of Bifidobacterium. The importance of the maternal vaginal microbiome as a source of infant gut microbiota is also discussed by the authors.


Raquel Tobes