Bacteriophage Interactions with Mammalian Tissue: Therapeutic Applications.
Huh H, Wong S, St Jean J, Slavcev R
Adv Drug Deliv Rev. Jan 2019
COMMENT: This review discuss the bacteriophage interaction with the human body and their ability to penetrate various human tissues such as gut, brain, skin, circulatory and respiratory system, and its current applications in phage therapy.
Viruses are the most abundant entities in our biosphere and contribute the largest reservoir of genetic material. Bacteriophages (phages) are the natural predators of bacteria and are prevalent across the globe, including within the human microbiome.
Interest in the application of phages as therapeutic tools continues to grow due to their advantages for therapeutic use. However, phage therapy needs to overcome many challenges, therapeutic applications need to use very high titers to achieve efficacy, maintain sufficient numbers of phage for therapeutic activity involve routes of administration, phage type, frequency of administration, dosage, modifications of the phage capsid, interspecies differences in the mammalian host, and more. Phages also require thorough investigation of the immunological response they may elicit, as well as extensive purification steps prior to their administration.