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Antimicrobials from human skin commensal bacteria protect against Staphylococcus aureus and are deficient in atopic dermatitis.

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PubMed ID: 28228596

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Nakatsuji T, Chen TH, Narala S, Chun KA, Two AM, Yun T, Shafiq F, Kotol PF, Bouslimani A, Melnik AV, Latif H, Kim JN, Lockhart A, Artis K, David G, Taylor P, Streib J, Dorrestein PC, Grier A, Gill SR, Zengler K, Hata TR, Leung DY, Gallo RL

Sci Transl Med. Feb 2017

COMMENT:  This is a very interesting paper because the findings could be important considering to treat Atopic Dermatitis (AD) with commensal bacteria from healthy skin microbiomes. The authors searched for antimicrobial activity against Staphylococcus aureus analysing coagulase-negative Staphylococcus (CoNS) collected from the skin of healthy and AD subjects. Interestingly, CoNS strains with antimicrobial activity were common on the normal population but rare on AD subjects. The authors also reported that colonization by S. aureus correlated with low frequency of antimicrobial producing strains.  

Application of these antimicrobial producing CoNS strains in vivo to mice demonstrated their effect when compared with strains not producing those antimicrobials. Furthermore, reintroduction of antimicrobial CoNS strains to human subjects with AD decreased colonization by S. aureus. Thus, these results are estimulating for all the efforts trying to take advantage of skin flora to improve skin health. In summary, the authors conclude that commensal skin bacteria could protect against pathogens and that dysbiosis of the skin microbiome can lead to disease.

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Eduardo Pareja