Antibiotic-induced perturbations in gut microbial diversity influences neuro-inflammation and amyloidosis in a murine model of Alzheimer's disease.
Minter MR, Zhang C, Leone V, Ringus DL, Zhang X, Oyler-Castrillo P, Musch MW, Liao F, Ward JF, Holtzman DM, Chang EB, Tanzi RE, Sisodia SS
Sci Rep. 2016. doi: 10.1038/srep30028
COMMENT: Alzheimer disease cognitive decline correlates mainly with neuroinflamation and microgliosis. It has been described how gut microbiome influences brain function in part modulating host innate immunity.
The authors describe how long term antibiotic administration produces changes in the gut microbiota and a coincident attenuated plaque-localised microglial and astrocyte reactivity. Thus, gut microbiota community diversity can regulate host innate immunity mechanisms that impact Aβ amyloidosis. Al this work has been done in the mouse model for Alzheimer disease APPSWE/PS1ΔE9.