Analysis of Fusobacterium persistence and antibiotic response in colorectal cancer.

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PubMed ID: 29170280

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Bullman S, Pedamallu CS, Sicinska E, Clancy TE, Zhang X, Cai D, Neuberg D, Huang K, Guevara F, Nelson T, Chipashvili O, Hagan T, Walker M, Ramachandran A, Diosdado B, Serna G, Mulet N, Landolfi S, Ramon Y Cajal S, Fasani R, Aguirre AJ, Ng K, Élez E, Ogino S, Tabernero J, Fuchs CS, Hahn WC, Nuciforo P, Meyerson M

Science. 12 2017. doi: 10.1126/science.aal5240

COMMENT: Fusobacterium nucleatum has been detected in colorectal cancer tissues in multiple works. In this work the authors detect Fusobacterium nucleatum and other bacteria that also are in the microenvironment of the primary tumour in distal metastases. It appears that the cancer cells that form metastases in distal places travel accompanied by the bacteria of the primary tumor microenvironment. 

Here we show that colonization of human colorectal cancers with Fusobacterium and its associated microbiome-including Bacteroides, Selenomonas, and Prevotella species-is maintained in distal metastases, demonstrating microbiome stability between paired primary and metastatic tumors. 

Using the approach of mouse xenograft of human primary colorectal adenocarcinomas the authors were able to detect viable Fusobacterium and its associated microbiome through successive passages. The further use of antibiotics reduced Fusobacterium load, cancer proliferation, and tumor growth. These important findings open the possibility of the potential use of antibiotics in Fusobacterium-associated colorectal cancer treatment.


Raquel Tobes