A subpopulation of high IL-21-producing CD4(+) T cells in Peyer's Patches is induced by the microbiota and regulates germinal centers.
Jones L, Ho WQ, Ying S, Ramakrishna L, Srinivasan KG, Yurieva M, Ng WP, Subramaniam S, Hamadee NH, Joseph S, Dolpady J, Atarashi K, Honda K, Zolezzi F, Poidinger M, Lafaille JJ, Curotto de Lafaille MA
Sci Rep. 2016. doi: 10.1038/srep30784
COMMENT: T follicular helper (Tfh) cells are crucial to the development of T cell-dependent antibody responses and produce IL-21 which is important for B cell responses. IL-21 also promotes the production of IgA in the gut. In fact IL-21 is abundant in Peyer's Patches due to stimulation of the microbiota.
This study identifies a subpopulation of Tfh specific of the Peyer's Patches and highly producing IL_21. This subpopulation required the microbiome to develop and its ablation reduced the number of Peyer's Patches and a change in microbiome composition.
In summary, new interesting results highlighting the interplay microbiome - Immune system