A defined commensal consortium elicits CD8 T cells and anti-cancer immunity.
Tanoue T, Morita S, Plichta DR, Skelly AN, Suda W, Sugiura Y, Narushima S, Vlamakis H, Motoo I, Sugita K, Shiota A, Takeshita K, Yasuma-Mitobe K, Riethmacher D, Kaisho T, Norman JM, Mucida D, Suematsu M, Yaguchi T, Bucci V, Inoue T, Kawakami Y, Olle B, Roberts B, Hattori M, Xavier RJ, Atarashi K, Honda K
Nature. Jan 2019. doi: 10.1038/s41586-019-0878-z
COMMENT: The authors identify a consortium of 11 bacterial strains capable of inducing IFN-gamma producing CD8 T cells at the intestine. Results in mice show that the consortium enhanced resistance to Listeria monocytogenes and efficacy of immunotherapy based on checkpoint inhibitors
In this study, we have identified 11 healthy human-associated bacterial strains that act together to induce IFNγ+ CD8 T cells, confer resistance to the intracellular pathogen Listeria, and are effective at inhibiting tumour growth in conjunction with ICIs. More research will be needed to determine the cellular and molecular mechanism by which the 11 strains effect the observed local and systemic immunomodulation