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1,520 reference genomes from cultivated human gut bacteria enable functional microbiome analyses.

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PubMed ID: 30718868

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Zou Y, Xue W, Luo G, Deng Z, Qin P, Guo R, Sun H, Xia Y, Liang S, Dai Y, Wan D, Jiang R, Su L, Feng Q, Jie Z, Guo T, Xia Z, Liu C, Yu J, Lin Y, Tang S, Huo G, Xu X, Hou Y, Liu X, Wang J, Yang H, Kristiansen K, Li J, Jia H, Xiao L

Nat Biotechnol. Feb 2019. doi: 10.1038/s41587-018-0008-8

COMMENT: 1,520 draft reference genomes of culturable bacteria from human gut microbiomes from healthy donors.

The authors present in this article the Culturable Genome Reference Collection, a collection of 1520 high-quality, non-redundant, draft genomes from culturable bacteria from gut microbiomes of healthy donors.

The 1520 genomes were selected from more than 6000 cultivated bacteria from fecal samples as they covered all major phyla and genera in the human gut microbiome. Out of this 1520 genomes 264 were not found in public genomic databases. The public release of this vast genome catalog of human gut bacteria is particularly useful for functional metagenomics analysis. As a proof of concept of the utility of the catalog the authors annotate the functions of 338 bacterial species and carry out a pan-genome analysis of 38 bacterial species that reveal significant differences in the functions found in their core and accesory genomes.

Sequencing data and genome assemblies are publicly available at the NCBI database under the accession number PRJNA482748 https://www.ncbi.nlm.nih.gov/bioproject/PRJNA482748

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Marina Manrique