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Commented preprints


 

Cariogenic Streptococcus mutans produces strain-specific antibiotics that impair commensal colonization
06/09/2019
Publication

Cariogenic Streptococcus mutans produces strain-specific antibiotics that impair commensal colonization

Xiaoyu Tang, Yuta Kudob , Jonathon Baker , Sandra LaBonte , Peter A. Jordan, Shaun M. K. McKinnie, Jian Guo, Tao Huan, Bradley S. Moore and Anna Edlun.  bioRxiv Preprint first posted online Sep. 4, 2019; doi: http://dx.doi.org/10.1101/755025..

COMMENT: This work is focused on the analysis of biosynthetic gene clusters in Streptococcus mutans able to produce small active molecules that could give competitive advantage to this abundant bacteria abundant in dental plaque and involved... + info

Resident microbial communities inhibit growth and antibiotic resistance evolution of Escherichia coli in human gut microbiome samples
24/08/2019
Publication

Resident microbial communities inhibit growth and antibiotic resistance evolution of Escherichia coli in human gut microbiome samples

Michael Baumgartner, Florian Bayer, Angus Buckling, Alex R. Hall.  bioRxiv preprint first posted online Aug. 20, 2019; doi: http://dx.doi.org/10.1101/741439 .

COMMENT: This work shows how the resident microbial communities can suppress the growth and colonization by focal Escherichia coli and can prevent the acquisition of antibiotic resistance after beta-lactam antibiotic exposure. + info

Assembly-free single-molecule nanopore sequencing recovers complete virus genomes from natural microbial communities
23/05/2019
Publication

Assembly-free single-molecule nanopore sequencing recovers complete virus genomes from natural microbial communities

John Beaulaurier, Elaine Luo, John Eppley, Paul Den Uyl, Xiaoguang Dai, Daniel J Turner, Matthew Pendelton, et al..  doi: https://doi.org/10.1101/619684. Posted in BioRxiv on Apr. 26, 2019..

COMMENT: The main objective was to develop a method to recover viral genome sequences from metagenomics samples making use of long reads. + info

Rapidly processed stool swabs approximate stool microbiota profiles
05/02/2019
Publication

Rapidly processed stool swabs approximate stool microbiota profiles

Nicholas A. Bokulich, Juan Maldonado, Dae-Wook Kang, Rosa Krajmalnik-Brown and J. Gregory Caporaso.

doi: http://dx.doi.org/10.1101/524512. Posted in BioRxiv on Jan. 18, 2019.

COMMENT: Under certain... + info

Mobile genetic element insertions drive antibiotic resistance across pathogens
27/01/2019
Publication

Mobile genetic element insertions drive antibiotic resistance across pathogens

Durrant MG, Li MM,  Siranosian B,  Bhatt AS  doi: http://dx.doi.org/10.1101/527788. Posted in BioRxiv on Jan. 23, 2019.

COMMENT: This work describes a new... + info

HLA alleles associated with risk of ankylosing spondylitis and rheumatoid arthritis influence the gut microbiome
24/01/2019
Publication

HLA alleles associated with risk of ankylosing spondylitis and rheumatoid arthritis influence the gut microbiome

Mark Asquith et al. doi: https://doi.org/10.1101/517813.  Posted in BioRxiv on January 16, 2019.

COMMENT: The main objective of the study is to find out if the discrete gut microbiome features found in patients with ankylosing spondylitis (AS) and rheumatoid arthritis (RA) are a cause or a consequence of having HLA risk alleles. To prove... + info

Oral iron exacerbates colitis and influences the intestinal microbiome
25/08/2018
Publication

Oral iron exacerbates colitis and influences the intestinal microbiome

Authors: Awad Mahalhal, Jonathan M. Williams, Sophie Johnson, Nicholas Ellaby, Carrie A. Duckworth, Michael D. Burkitt, Xuan Liu, Georgina L. Hold, Barry J. Campbell, D. Mark Pritchard, Chris S. Probert

bioRxiv... + info

Architecture of a bacterial type II secretion system
25/08/2018
Publication

Architecture of a bacterial type II secretion system

Authors: Anastasia A Chernyatina and Harry H Low. bioRxiv preprint first posted online Aug. 22, 2018.

COMMENT: In this Preprint the authors, using a fusion of negative stain and cryo-electron... + info

Next-generation sequencing in neuropathological diagnosis of infections of the nervous system
05/09/2016
Publication

Next-generation sequencing in neuropathological diagnosis of infections of the nervous system

Authors: Steven L. Salzberg, Florian P. Breitwieser, Anupama Kumar, Haiping Hao, Peter Burger, Fausto J. Rodriguez, Michael Lim, Alfredo Quiñones-Hinojosa, Gary L. Gallia, Jeffrey A Tornheim, Michael T. Melia, Cynthia L. Sears and Carlos A. Pardo.  Preprint posted in bioRxiv online Feb. 9, 2016.

COMMENT: In this work NGS is used for differential diagnosis of nervous system pathologies whose diagnosis with conventional methods is problematic.  + info

Total RNA Sequencing reveals microbial communities in human blood and disease specific effects
24/08/2016
Publication

Total RNA Sequencing reveals microbial communities in human blood and disease specific effects

Authors: Serghei Mangul, Loes M Olde Loohuis, Anil P Ori, Guillaume Jospin, David Koslicki, Harry Taegyun Yang, Timothy Wu, Marco P Boks, Catherine Lomen-Hoerth, Martina Wiedau-Pazos, Rita M Cantor, Willem M de Vos,René S Kahn, Eleazar Eskin, Roel A Ophoff.  Preprint posted in BioRxiv on  June 7, 2016.

COMMENT: In this preprint the authors demostrate the potential use of total RNA to study microbes that inhabit the blood.  + info

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