Gut microbiome from Parkinson's disease patients induces enhanced motor dysfunction in mice

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Finally a clear relationship between the gut microbiome and Parkinson's disease (PD) has been pubished in Cell. In the article entitled "Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson’s Disease" Sampson  et al. publish that gut microbes are required for the neuroinflammatory responses motor deficits in a model of Parkinson’s disease in mice.

The authors highlight these facts:

  • Gut microbes promote alpha-synuclein-mediated motor deficits and brain pathology
  • Depletion of gut bacteria reduces microglia activation
  • The microbial metabolites short-chain fatty acids (SCFAs) modulate microglia and enhance PD pathophysiology
  • Human gut microbiota from PD patients induce enhanced motor dysfunction in mice

Newly the conection between gut microbiome and brain has been confirmed and the long time ago searched involvement of gut microbiome in Parkinson's disease pathophysiology has been confirmed with the findings of this work.

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Raquel Tobes