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Akkermansia muciniphila and Acinetobacter calcoaceticus are increased in Multiple Sclerosis patients gut and induce proinflammatory responses in blood

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22/10/2017

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Searching for a relationships between gut microbiome and Multiple sclerosis (MS) the authors identified specific bacterial taxa that were significantly associated with MS: 

Akkermansia muciniphila and Acinetobacter calcoaceticus, both increased in MS patients, induced proinflammatory responses in human peripheral blood mononuclear cells and in monocolonized mice. In contrast, Parabacteroides distasonis, which was reduced in MS patients, stimulated antiinflammatory IL-10–expressing human CD4+CD25+ T cells and IL-10+FoxP3+ Tregs in mice.

These findings are a good initial basis for the development of microbiome-based and immune-mediated therapeutics for Multiple Sclerosis.

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Contributor

Raquel Tobes