Newborn and maternal microbiome. Commented references 2019.
Shao Y, Forster SC, Tsaliki E, Vervier K, Strang A, Simpson N, Kumar N, Stares MD, Rodger A, Brocklehurst P, Field N, Lawley TD. Nature. Sep 2019. doi: 10.1038/s41586-019-1560-1.
COMMENT: This study analyzes the microbiome of 596 full-term babies, 314 of them were vaginal births and 282 were via caesarean section. The analysis was mainly done using shotgun metagenomics approaches. The results... + info
McDonald B, McCoy KD. Science. Sep 2019. doi: 10.1126/science.aay0618.
COMMENT: In this work the authors analyze the most important findings done during last years about maternal and newborn microbiota reviewing its involvement in the susceptibility to some illnesses. + info
Yang YN, Yang YSH, Lin IH, Chen YY, Lin HY, Wu CY, Su YT, Yang YJ, Yang SN, Suen JL. Food Chem Toxicol. Oct 2019.
COMMENT: This work studies the effect of di-(2-ethylhexyl) phthalate (DEHP), a common plasticizer, over newborn microbiota by means of a prospective cohort study. Newborns with respiratory distress who were given intravenous infusions... + info
Younge N, McCann JR, Ballard J, Plunkett C, Akhtar S, Araújo-Pérez F, Murtha A, Brandon D, Seed PC. JCI Insight. Sep 2019. doi: 10.1172/jci.insight.127806127806.
COMMENT: The authors study the microbiota of human and mouse dyads (mother and child) localizing viable bacteria in the fetus: + info
Drago L, Panelli S, Bandi C, Zuccotti G, Perini M, D'Auria E. J Clin Med. Aug 2019.
COMMENT: This review is oriented to help the pediatricians to manage and interpret microbiome studies. + info
Ketonuria Is Associated with Changes to the Abundance of Roseburia in the Gut Microbiota of Overweight and Obese Women at 16 Weeks Gestation: A Cross-Sectional Observational Study.
Robinson H, Barrett H, Gomez-Arango L, McIntyre HD, Callaway L, Dekker Nitert M. Nutrients. Aug 2019.
COMMENT: This work was oriented to analyze the differences in the composition of the gut microbiota in pregnant women with and without ketonuria at 16 weeks gestation using 16S-based taxonomic profiling. The study includes 11 women with... + info
Borghi E, Massa V, Severgnini M, Fazio G, Avagliano L, Menegola E, Bulfamante GP, Morace G, Borgo F. Reprod Sci. Aug 2019. doi: 10.1177/1933719118804411.
COMMENT: This work is focused on the study of the maternal-derived microbial colonization of the newborn and on the analysis of fetal colonization before parturition from other not maternal microbiomes. + info
Tang M, Xu C, Chen K, Yan Q, Mao W, Liu W, Ritz B. Environ Pollut. Jul 2019.
COMMENT: This work is focused on the possible associations between environmental pollutants and the microbial composition of human colostrum studying the influence of hexachlorocyclohexane (HCH), measured via gas chromatography, in the microbial... + info
Metaproteomic investigation to assess gut microbiota shaping in newborn mice: A combined taxonomic, functional and quantitative approach.
Levi Mortera S, Soggiu A, Vernocchi P, Del Chierico F, Piras C, Carsetti R, Marzano V, Britti D, Urbani A, Roncada P, Putignani L. J Proteomics. Jul 2019.
COMMENT: This work is centred on the use of metaproteomics for analyzing newborn microbiota. The authors present a method based on the use of liquid chromatography (LC) tandem mass spectrometry (MS) to monitor mouse gut... + info
Hu J, Ly J, Zhang W, Huang Y, Glover V, Peter I, Hurd YL, Nomura Y. Dev Psychobiol. Jul 2019. doi: 10.1002/dev.21837.
COMMENT: This work it has been studied the influence of the mother's psychological state during pregnancy over the newborn microbiome. + info
Impact of Early Exposure to Cefuroxime on the Composition of the Gut Microbiota in Infants Following Cesarean Delivery.
Kamal SS, Hyldig N, Krych Ł, Greisen G, Krogfelt KA, Zachariassen G, Nielsen DS. J Pediatr. Jul 2019.
COMMENT: The goal of this work was to assess in cesarean deliveries if prophylactic antibiotics have some impact on gut microbiota colonization or in antibiotic susceptibility of the gut bacteria in the newborn. + info
Gopalakrishna KP, Macadangdang BR, Rogers MB, Tometich JT, Firek BA, Baker R, Ji J, Burr AHP, Ma C, Good M, Morowitz MJ, Hand TW. Nat Med. Jul 2019. doi: 10.1038/s41591-019-0480-9.
COMMENT: This work demonstrates that maternal immunoglobulin A (IgA) is an important factor for protection against Necrotizing enterocolitis (NEC), a neonatal disease with high morbidity and mortality associated with intestinal inflammation driven... + info
Variation of cultured skin microbiota in mothers and their infants during the first year postpartum.
Gaitanis G, Tsiouri G, Spyridonos P, Stefos Τ, Stamatas GN, Velegraki A, Bassukas ID. Pediatr Dermatol. Jul 2019. doi: 10.1111/pde.13829.
COMMENT: This work presents the results of a longitudinal study of culturable skin bacteria in the mother-infant dyad during the first year of life. The study included 17 mother-infant dyads sampled 24 hours postpartum and at 3, 6, 9, and... + info
Early-Onset Preeclampsia Is Associated With Gut Microbial Alterations in Antepartum and Postpartum Women.
Lv LJ, Li SH, Li SC, Zhong ZC, Duan HL, Tian C, Li H, He W, Chen MC, He TW, Wang YN, Zhou X, Yao L, Yin AH. Front Cell Infect Microbiol. 2019. doi: 10.3389/fcimb.2019.00224.
COMMENT: This study analyzes gut microbiome in women with early-onset preeclampsia (PE) and in normotensive, uncomplicated pregnant women. + info
Microbiota of human precolostrum and its potential role as a source of bacteria to the infant mouth.
Ruiz L, Bacigalupe R, García-Carral C, Boix-Amoros A, Argüello H, Silva CB, de Los Angeles Checa M, Mira A, Rodríguez JM. Sci Rep. Jun 2019. doi: 10.1038/s41598-019-42514-1.
COMMENT: This work is focused on the origin of bacteria in human milk. Enteromammary route, mother skin or infant mouth are some of the proposed possibilities. The authors search for a response analyzing precolostrum samples collected... + info
Dominguez-Bello MG. Nat Med. 06 2019. doi: 10.1038/s41591-019-0483-6.
COMMENT: This is a comment about 2 articles of Nature Medicine about maternal vaginal microbiome and their relationships with preterm birth and ethnicity: + info
Sato Y, Sakurai K, Tanabe H, Kato T, Nakanishi Y, Ohno H, Mori C. J Dev Orig Health Dis. May 2019. doi: 10.1017/S2040174419000138.
COMMENT: In this work the authors study the association between maternal gut microbiota and fetal growth. + info
Lactobacillus paracasei PS23 reduced early-life stress abnormalities in maternal separation mouse model.
Liao JF, Hsu CC, Chou GT, Hsu JS, Liong MT, Tsai YC. Benef Microbes. Apr 2019. doi: 10.3920/BM2018.0077.
COMMENT: This work presents the effects of administration of a probiotic, Lactobacillus paracasei PS23 (PS23), to Maternal separation mice (model for inducing stress and depression) against psychological traits including anxiety and dep... + info
Mycobiome Profiles in Breast Milk from Healthy Women Depend on Mode of Delivery, Geographic Location, and Interaction with Bacteria.
Boix-Amorós A, Puente-Sánchez F, du Toit E, Linderborg KM, Zhang Y, Yang B, Salminen S, Isolauri E, Tamames J, Mira A, Collado MC. Appl Environ Microbiol. May 2019.
COMMENT: The goal of this work was to determine whether the healthy human breast milk mycobiota depends on geographical location and delivery mode and what is the interaction between mycobiome and bacterial microbiome in ... + info
Sajdel-Sulkowska EM, Makowska-Zubrycka M, Czarzasta K, Kasarello K, Aggarwal V, Bialy M, Szczepanska-Sadowska E, Cudnoch-Jedrzejewska A. Cerebellum. Apr 2019. doi: 10.1007/s12311-018-0970-1.
COMMENT: This review analyzes the alterations in gut microbiome-brain axis that prematurity and autism have in common. + info
The Profile of Human Milk Metabolome, Cytokines, and Antibodies in Inflammatory Bowel Diseases Versus Healthy Mothers, and Potential Impact on the Newborn.
Meng X, Dunsmore G, Koleva P, Elloumi Y, Wu RY, Sutton RT, Ambrosio L, Hotte N, Nguyen V, Madsen KL, Dieleman LA, Chen H, Huang V, Elahi S. J Crohns Colitis. Mar 2019. doi: 10.1093/ecco-jcc/jjy186.
COMMENT: In this work the composition of human milk in terms of antibodies, cytokines, and metabolites is analyzed in IBD mothers to evaluate the impact on newborn immune system. + info
Cervicovaginal microbiota and local immune response modulate the risk of spontaneous preterm delivery.
Elovitz MA, Gajer P, Riis V, Brown AG, Humphrys MS, Holm JB, Ravel J. Nat Commun. 03 2019. doi: 10.1038/s41467-019-09285-9.
COMMENT: This work analyzes the relationships between cervicovaginal microbiome and preterm birth. + info
Maternal antibiotic prophylaxis affects Bifidobacterium spp. counts in the human milk, during the first week after delivery.
Padilha M, Iaucci JM, Cabral VP, Diniz EMA, Taddei CR, Saad SMI. Benef Microbes. Mar 2019. doi: 10.3920/BM2018.0046.
COMMENT: This work is oriented to evaluate the impact of the maternal antibiotic prophylaxis (MAP) on the abundance of Bifidobacterium spp in milk because these bacteria have been associated to infant health benefits and it is known... + info
Birth Mode, Breastfeeding, Pet Exposure, and Antibiotic Use: Associations With the Gut Microbiome and Sensitization in Children.
Kim H, Sitarik AR, Woodcroft K, Johnson CC, Zoratti E. Curr Allergy Asthma Rep. Mar 2019. doi: 10.1007/s11882-019-0851-9.
COMMENT: This is a review of the literature that is focused on specific factors as pet keeping, breastfeeding, antibiotic use, and mode of delivery that influence the infant gut microbiome and atopy. + info
Prevalence of and risk factors for abnormal vaginal flora and its association with adverse pregnancy outcomes in a rural district in north-east Bangladesh.
Baqui AH, Lee ACC, Koffi AK, Khanam R, Mitra DK, Dasgupta SK, Uddin J, Ahmed P, Rafiqullah I, Rahman M, Quaiyum A, Koumans EH, Christian P, Saha SK, Mullany LC, Labrique A. Acta Obstet Gynecol Scand. Mar 2019. doi: 10.1111/aogs.13492.
COMMENT: In this work the authors report the risk factors for abnormal vaginal flora (AVF) and association of persistent AVF with adverse perinatal outcomes. + info
Probiotics for the Prevention of Gestational Diabetes Mellitus in Overweight and Obese Women: Findings From the SPRING Double-Blind Randomized Controlled Trial.
Callaway LK, McIntyre HD, Barrett HL, Foxcroft K, Tremellen A, Lingwood BE, Tobin JM, Wilkinson S, Kothari A, Morrison M, O'Rourke P, Pelecanos A, Dekker Nitert M. Diabetes Care. 03 2019. doi: 10.2337/dc18-2248.
COMMENT: The objective of this work was to determine whether probiotics (Lactobacillus rhamnosus and Bifidobacterium animalis subspecies lactis) administered from the second trimester in overweight and obese women prevent gestational diabetes... + info
Enterobacteria vaginal colonization among patients with preterm premature rupture of membranes from 24 to 34 weeks of gestation and neonatal infection risk.
Merello M, Lotte L, Gonfrier S, Eleni Dit Trolli S, Casagrande F, Ruimy R, Bongain A. J Gynecol Obstet Hum Reprod. Mar 2019.
COMMENT: The aim of this study was to assess, for Premature rupture of membranes (PROM) occurring at 23-34 weeks' gestation, if the presence of ampicillin-resistant enterobacteria in the vaginal microbiome increases the risk of... + info
Environmental toxicants in breast milk of Norwegian mothers and gut bacteria composition and metabolites in their infants at 1 month.
Iszatt N, Janssen S, Lenters V, Dahl C, Stigum H, Knight R, Mandal S, Peddada S, González A, Midtvedt T, Eggesbø M. Microbiome. 02 2019. doi: 10.1186/s40168-019-0645-2.
COMMENT: In this work the authors investigated the effect produces by the environmental toxicants in breastmilk over the composition of the infant gut microbiome at 1 month. + info
Does birth mode modify associations of maternal pre-pregnancy BMI and gestational weight gain with the infant gut microbiome?
Singh SB, Madan J, Coker M, Hoen A, Baker ER, Karagas MR, Mueller NT. Int J Obes (Lond). Feb 2019. doi: 10.1038/s41366-018-0273-0.
COMMENT: This work tests the hypothesis that birth mode modify the transmission of obesity-associated microbiota from mother-to-newborn. For that the authors analyze 335 mother-infant pairs in the New Hampshire Birth Cohort analyzing the... + info
Eczema-protective probiotic alters infant gut microbiome functional capacity but not composition: sub-sample analysis from a RCT.
Murphy R, Morgan XC, Wang XY, Wickens K, Purdie G, Fitzharris P, Otal A, Lawley B, Stanley T, Barthow C, Crane J, Mitchell EA, Tannock GW. Benef Microbes. Feb 2019. doi: 10.3920/BM2017.019.
COMMENT: In this work the authors analyze the impact of early life probiotic exposure on the composition and functional capacity of infant gut in relation to age, delivery mode, antibiotics, pets and eczema. + info