Newborn and maternal microbiome. Commented references 2018.
Ho TTB, Groer MW, Kane B, Yee AL, Torres BA, Gilbert JA, Maheshwari A. Microbiome. 09 2018. doi: 10.1186/s40168-018-0547-8.
COMMENT: This work is centred on the study of intestinal dysbiosis frequently observed in preterm infants. + info
Maternal Administration of Probiotic or Prebiotic Prevents Male Adult Rat Offspring against Developmental Programming of Hypertension Induced by High Fructose Consumption in Pregnancy and Lactation.
Hsu CN, Lin YJ, Hou CY, Tain YL. Nutrients. Sep 2018.
COMMENT: This work is centred on the study in rats of the hypertension that maternal high-fructose (HF) diet can induce in her adult male offspring. Considering that the effect of HF-induced programmed hypertension could be mediated... + info
Wang J, Zheng J, Shi W, Du N, Xu X, Zhang Y, Ji P, Zhang F, Jia Z, Wang Y, Zheng Z, Zhang H, Zhao F. Gut. 09 2018. doi: 10.1136/gutjnl-2018-315988.
COMMENT: This work is focused on the possible dysbiosis of maternal and neonatal microbiota associated with gestational diabetes mellitus (GDM) and on the potential risks of that for the newborn. + info
Romano KA, Rey FE. Lab Anim (NY). 09 2018. doi: 10.1038/s41684-018-0129-1.
COMMENT: The objective of this works was to find evidences supporting the idea that environmental stress experienced in utero establishes a predisposition in the newborn to the development of chronic diseases later in life. + info
Tapiainen T, Paalanne N, Tejesvi MV, Koivusaari P, Korpela K, Pokka T, Salo J, Kaukola T, Pirttilä AM, Uhari M, Renko M. Pediatr Res. 09 2018. doi: 10.1038/pr.2018.29.
COMMENT: The goal of this research was to analyze the microbiome of the first stool of newborns. They analyzed 212 samples of the first-pass meconium using 16S rRNA amplicon sequencing to investigate whether maternal factors during pregnancy... + info
Plaza-Díaz J, Fontana L, Gil A. Nutrients. Aug 2018.
COMMENT: This review is centred on Human Milk Oligosaccharides (HMOs), key components of maternal human milk. + info
Bardanzellu F, Fanos V, Strigini FAL, Artini PG, Peroni DG. Front Pediatr. 2018. doi: 10.3389/fped.2018.00215.
COMMENT: This work has the objective of the characterization of Maternal breast milk metabolome and microbiome. + info
Strain-Level Analysis of Mother-to-Child Bacterial Transmission during the First Few Months of Life.
Yassour M, Jason E, Hogstrom LJ, Arthur TD, Tripathi S, Siljander H, Selvenius J, Oikarinen S, Hyöty H, Virtanen SM, Ilonen J, Ferretti P, Pasolli E, Tett A, Asnicar F, Segata N, Vlamakis H, Lander ES, Huttenhower C, Knip M, Xavier RJ. Cell Host Microbe. 07 2018.
COMMENT: This is a study of a prospective birth cohort of 44 infants and their mothers, sampled longitudinally in the first months of each child's life. The authors analyze the microbiomes comparing bacterial strains across and within... + info
Nyangahu DD, Lennard KS, Brown BP, Darby MG, Wendoh JM, Havyarimana E, Smith P, Butcher J, Stintzi A, Mulder N, Horsnell W, Jaspan HB. Microbiome. 07 2018. doi: 10.1186/s40168-018-0511-7.
COMMENT: The objective of this study was to analyze how maternal microbiome determines infant immunity. For that, the authors analyze longitudinally (at several time points) adaptive immunity and gut microbiome in mice dyads (dams... + info
Maternal diet during pregnancy is related with the infant stool microbiome in a delivery mode-dependent manner.
Lundgren SN, Madan JC, Emond JA, Morrison HG, Christensen BC, Karagas MR, Hoen AG. Microbiome. 07 2018. doi: 10.1186/s40168-018-0490-8.
COMMENT: This work was designed to study the association of maternal diet during pregnancy with the infant gut microbiome. For that, microbiomes of the children and diet of the mothers were analyzed at 6 weeks post-delivery in 145... + info
Loewen K, Monchka B, Mahmud SM, 't Jong G, Azad MB. Eur Respir J. 07 2018.
COMMENT: The goal of this work was to analyze the association between prenatal antibiotic exposure and childhood asthma. This was the design of the study: + info
Rosado MM, Aranburu A, Scarsella M, Cascioli S, Giorda E, Del Chierico F, Mortera SL, Mortari EP, Petrini S, Putignani L, Carsetti R. Immunol Lett. 07 2018.
COMMENT: This work is centred in studying how colonizing bacteria impact the maturation of the spleen. + info
Freitas AC, Bocking A, Hill JE, Money DM. Microbiome. 06 2018. doi: 10.1186/s40168-018-0502-8.
COMMENT: The objective of this study was to analyze vaginal microbiome in pregnant women who had spontaneous preterm birth (sPTB) and in pregnant women who delivered at term and compare the microbiomes of both groups to get new insights... + info
Valentine G, Chu DM, Stewart CJ, Aagaard KM. Clin Perinatol. Jun 2018 doi https://doi.org/10.1016/j.clp.2018.01.008.
COMMENT: It is widely described the relation of the human microbiome with human common diseases like obesity, type II diabetes and inflammatory bowel disease to name a few. It is also thought that this relation might start in early life during... + info
Prenatal exposure to endocrine disrupting chemicals and risk of being born small for gestational age: Pooled analysis of seven European birth cohorts.
Govarts E, Iszatt N, Trnovec T, de Cock M, Eggesbø M, Palkovicova Murinova L, van de Bor M, Guxens M, Chevrier C, Koppen G, Lamoree M, Hertz-Picciotto I, Lopez-Espinosa MJ, Lertxundi A, Grimalt JO, Torrent M, Goñi-Irigoyen F, Vermeulen R, Legler J, Schoeters G. Environ Int. 06 2018.
COMMENT: The goal of this work was to investigate whether some endocrine disrupting chemicals (EDCs) are associated with the adverse birth outcome Small for Gestational Age (SGA). + info
The influence of maternal vaginal flora on the intestinal colonization in newborns and 3-month-old infants.
Gabriel I, Olejek A, Stencel-Gabriel K, Wielgoś M. J Matern Fetal Neonatal Med. Jun 2018. doi: 10.1080/14767058.2017.1319352.
COMMENT: The objective of this work was to estimate the role of maternal vaginal microbiome on the development of intestinal microbiome in neonates and 3-month-old infants. + info
Maternal omega-3 fatty acids regulate offspring obesity through persistent modulation of gut microbiota.
Robertson RC, Kaliannan K, Strain CR, Ross RP, Stanton C, Kang JX. Microbiome. 05 2018. doi: 10.1186/s40168-018-0476-6.
COMMENT: This work was oriented to get insight about how the fatty acid profile of the maternal diet during gestation and lactation influences the offspring gut microbiota and subsequent metabolic health outcomes. + info
Niimi K, Usami K, Fujita Y, Abe M, Furukawa M, Suyama Y, Sakai Y, Kamioka M, Shibata N, Park EJ, Sato S, Kiyono H, Yoneyama H, Kitazawa H, Watanabe K, Nochi T, Aso H. Mucosal Immunol. 05 2018. doi: 10.1038/mi.2017.90.
COMMENT: The goal of this work was to study how the immune and microbial environments of mammary gland protect the mother and the newborn from infectious diseases. + info
Bifidobacteria isolated from vaginal and gut microbiomes are indistinguishable by comparative genomics.
Freitas AC, Hill JE. PLoS One. 2018. doi: 10.1371/journal.pone.0196290.
COMMENT: In this work the genomes of Bifidobacterium breve and Bifidobacterium longum of gut and vaginal isolates were comapared to assess whether they were distinguishable based on their genome content. + info
McCoy KD, Thomson CA. J Immunol. 04 2018. doi: 10.4049/jimmunol.1701776.
COMMENT: In this review the authors sumarize the current knowledge about how the microbiota can impact hematopoiesis, with a especial focus on the effects of maternal and newborn microbiome over bone marrow. + info
Korpela K, Costea P, Coelho LP, Kandels-Lewis S, Willemsen G, Boomsma DI, Segata N, Bork P. Genome Res. 04 2018. doi: 10.1101/gr.233940.117.
COMMENT: This work is focused on transmission of bacteria from mother to newborn. The authors realize that it is needed to track the specific microbial strains for clarifying where the intestinal bacteria come from, how long the... + info
Maternal antibiotic exposure during pregnancy and hospitalization with infection in offspring: a population-based cohort study.
Miller JE, Wu C, Pedersen LH, de Klerk N, Olsen J, Burgner DP. Int J Epidemiol. 04 2018. doi: 10.1093/ije/dyx272.
COMMENT: The goal of this work was to investigate the relationship between maternal antibiotic exposure before and during pregnancy, and risk of childhood hospitalization with infection. + info
Sprockett D, Fukami T, Relman DA. Nat Rev Gastroenterol Hepatol. 04 2018. doi: 10.1038/nrgastro.2017.173.
COMMENT: The authors of this work analyze whether the order and timing of species arrival to gut microbiome determine future microbiome states. They also discuss factors that alter microbial transmission, such as delivery mode, diet and breastfeeding,... + info
Stiemsma LT, Michels KB. Pediatrics. 04 2018.
COMMENT: This work is centred around the microbiome as a mechanistic mediator in the Developmental Origins of Health and Disease with a especial focus on newborn microbiome. + info
Prenatal and postnatal antibiotic exposure influences the gut microbiota of preterm infants in neonatal intensive care units.
Zou ZH, Liu D, Li HD, Zhu DP, He Y, Hou T, Yu JL. Ann Clin Microbiol Antimicrob. Mar 2018. doi: 10.1186/s12941-018-0264-y.
COMMENT: To know whether gut microbiota from preterm infants, and drug resistant strains in the neonatal intensive care unit (NICU) were related the authors analyzed 28 preterm infants classified in 2 groups: the PAT (prenatal antibiotic therapy)... + info
Effect of prenatal administration of low dose antibiotics on gut microbiota and body fat composition of newborn mice.
Yoshimoto A, Uebanso T, Nakahashi M, Shimohata T, Mawatari K, Takahashi A. J Clin Biochem Nutr. Mar 2018. doi: 10.3164/jcbn.17-53.
COMMENT: This work is oriented to investigate in mice the effect of prenatal administration of low-dose antibiotics on newborns' health in later life. The main effects that the authors found in the newborns were: + info
Independent of Birth Mode or Gestational Age, Very-Low-Birth-Weight Infants Fed Their Mothers' Milk Rapidly Develop Personalized Microbiotas Low in Bifidobacterium.
Butcher J, Unger S, Li J, Bando N, Romain G, Francis J, Mottawea W, Mack D, Stintzi A, O'Connor DL. J Nutr. 03 2018. doi: 10.1093/jn/nxx071.
COMMENT: The goal of this work was to characterize the development of the gut microbiota in exclusively mother's milk-fed Very-low-birth-weight (VLBW) infants and to describe their taxonomic profile to define a reference VLBW infant microbiota... + info
Chong CYL, Bloomfield FH, O'Sullivan JM. Nutrients. Feb 2018.
COMMENT: This review is focused on the factors that affect the development of the gastrointestinal (GI) microbiome during prenatal, perinatal to postnatal life. + info
Group B Streptococcal Maternal Colonization and Neonatal Disease: Molecular Mechanisms and Preventative Approaches.
Patras KA, Nizet V. Front Pediatr. 2018. doi: 10.3389/fped.2018.00027.
COMMENT: This review is centred on the colonization of newborn by Group B Streptococcus (GBS) during parturition from the maternal vaginal epithelium. This colonization can cause a serious infection in the vulnerable newborn. Bacterial... + info
Kang LJ, Koleva PT, Field CJ, Giesbrecht GF, Wine E, Becker AB, Mandhane PJ, Turvey SE, Subbarao P, Sears MR, Scott JA, Kozyrskyj AL. Brain Behav Immun. 02 2018.
COMMENT: The authors investigate in this work the differences in infant fecal sIgA concentrations according to the presence of maternal depressive symptoms during and after pregnancy. + info
Vaginal dysbiosis increases risk of preterm fetal membrane rupture, neonatal sepsis and is exacerbated by erythromycin.
Brown RG, Marchesi JR, Lee YS, Smith A, Lehne B, Kindinger LM, Terzidou V, Holmes E, Nicholson JK, Bennett PR, MacIntyre DA. BMC Med. 01 2018. doi: 10.1186/s12916-017-0999-x.
COMMENT: The authors study maternal vaginal microbiome prior to and following Preterm prelabour rupture of the fetal membranes (PPROM) and examine the impact of erythromycin prophylaxis on vaginal microbiome. + info
Makino H. Biosci Microbiota Food Health. 2018. doi: 10.12938/bmfh.18-011.
COMMENT: The origin of newborn gut microbiota is investigated in this work. The source of intestinal microbes in newborn is very important because some evidences suggest that this first intestinal bacterial colonization affects... + info
Wheeler S, Pryor K, Antczak B, Truong T, Murtha A, Seed P. J Neonatal Perinatal Med. 2018. doi: 10.3233/NPM-17111.
COMMENT: The objective of this work was to correlate cervical microbiota diversity with cervico-vaginal inflammation by race and delivery timing. + info